| Mutation | Y116S >>View Structure<< |
Region | LRR3 |
General number GPCRDB / Ballesteros-Extended | 0
3059 |
| Receptor | TSHR Human | Swiss-Prot
Crossreferences at GPCRDB |
| Phenotype | Constitutivity (compared to WT): Unknown
Cell-surface expression (%WT): 78
Binding affinity of native hormone: Unknown
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| Additional comments | This mutation is seen to disrupt ectodomain multimer formation according to Latif et al. | |
| Download | Download the flat text file of this mutant (more info here) | |
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| Reference #1 |
A tyrosine residue on the TSH receptor stabilizes multimer formation.
Latif R, Michalek K, Morshed SA, Davies TF
PLoS One. 2010 Feb 26;5(2):e9449. | Pubmed |