| Mutation | C646A |
Region | Other |
General number GPCRDB / Ballesteros-Extended | 0
0 |
| Receptor | FSHR Human | Swiss-Prot
Crossreferences at GPCRDB |
| Phenotype | Constitutivity (compared to WT): Unknown
Cell-surface expression (%WT): Unknown
Binding affinity of native hormone: Unchanged
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| Additional comments | C646 is palmitoylated. Lack of palmitoylation on this position significantly impairs cell surface membrane expression of the partially palmitoylated receptor. | |
| Download | Download the flat text file of this mutant (more info here) | |
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| Reference #1 |
Functional and structural roles of conserved cysteine residues in the carboxyl-terminal domain of the follicle-stimulating hormone receptor in human embryonic kidney 293 cells.
Uribe A, Zarinan T, Perez-Solis MA, Gutierrez-Sagal R, Jardon-Valadez E, Pineiro A, Dias JA, Ulloa-Aguirre A
Biol Reprod. 2008 May;78(5):869-82. Epub 2008 Jan 16. | Pubmed |