GRIS, the Glycoprotein-hormone Receptors Information System is dedicated to the collection and dissemination of data involving the three most known glycoprotein-hormone receptors (GpHRs): The thyrotropin receptor (TSHR), the follitropin receptor (FSHR) and the lutropin/ choriogonadotropin receptor (LHR/CGR).

GRIS collects, organises and presents to its visitors the most heterogenous data on GpHRs: sequences, models, mutational data, etc ...
The focus is mainly on mutational data and the transfer of these to structural information, i.e. the models.

GRIS offers possibilities to browse through all published GpHR mutations to date and (if known) to review the effects of the mutations.

A large part of GRIS is dedicated to GpHR molecular model analysis, including per residue detailed information.

We also go beyond this 'established' information. GRIS allows scientists to study and predict the effect of mutations in silico, using a very user-friendly web interface including molecular visualization using Jmol.

Scientists can also contribute the newest mutagenesis data to GRIS, keeping the database very up-to-date for the whole GpHR community.

Feedback on bugs or improvements are essential for everyone. Please don't hesitate to contact us.